Here is the complete list, arranged chronologically by designation. You can click on each trail to go the the NPS or BLM website specific for each trail.
| # | National Historic Trail | Designated | Short description |
|---|---|---|---|
| 1 | Oregon National Historic Trail | 1978 | Follows the 2,000-plus-mile emigrant route from Missouri to Oregon used by hundreds of thousands of settlers in the 1840s–1860s. |
| 2 | Mormon Pioneer National Historic Trail | 1978 | Commemorates the route followed by Mormon emigrants from Nauvoo, Illinois, to the Great Salt Lake Valley in Utah beginning in 1846. |
| 3 | Iditarod National Historic Trail | 1978 | Follows the historic network of trails across Alaska connecting Seward, Nome, and numerous Interior Alaska communities; associated with Native trade, mining, mail delivery, and the famous Iditarod route. |
| 4 | Lewis and Clark National Historic Trail | 1978 | Follows the route of the Corps of Discovery Expedition of 1804–1806 from the vicinity of St. Louis to the Pacific Coast and back. |
| 5 | Overmountain Victory National Historic Trail | 1980 | Commemorates the route of the American militia who crossed the southern Appalachians in 1780 and defeated British forces at the Battle of Kings Mountain. |
| 6 | Nez Perce (Nee-Me-Poo) National Historic Trail | 1986 | Follows the 1877 flight of the Nez Perce from their homeland toward Canada while attempting to avoid forced removal to a reservation. |
| 7 | Trail of Tears National Historic Trail | 1987 | Commemorates the forced removal of the Cherokee and other southeastern tribes to Indian Territory during the 1830s. |
| 8 | Santa Fe National Historic Trail | 1987 | Follows the 19th-century commercial and military route connecting Missouri with Santa Fe, New Mexico. |
| 9 | Juan Bautista de Anza National Historic Trail | 1990 | Follows the 1775–1776 expedition led by Juan Bautista de Anza from Mexico to San Francisco, which helped establish Spanish settlement in Alta California. |
| 10 | California National Historic Trail | 1992 | Commemorates the routes taken by emigrants traveling west to California during the great migration of the 1840s and 1850s, including routes associated with the California Gold Rush. |
| 11 | Pony Express National Historic Trail | 1992 | Follows the route of the short-lived Pony Express mail service between Missouri and California in 1860–1861. |
| 12 | Selma to Montgomery National Historic Trail | 1996 | Commemorates the 1965 voting-rights marches from Selma to Montgomery, Alabama, that helped lead to passage of the Voting Rights Act. |
| 13 | El Camino Real de Tierra Adentro National Historic Trail | 2000 | Follows the historic Spanish colonial road between Mexico City and northern New Mexico, used for trade, settlement, missionary activity, and military travel. |
| 14 | Ala Kahakai National Historic Trail | 2000 | Follows an ancient network of coastal trails around Hawaiʻi Island, connecting traditional Hawaiian communities, cultural sites, and resources. |
| 15 | Old Spanish National Historic Trail | 2002 | Commemorates the 19th-century trade route between Santa Fe, New Mexico, and Los Angeles, California, used by traders and pack trains. |
| 16 | El Camino Real de los Tejas National Historic Trail | 2004 | Follows the Spanish colonial road system through eastern Texas and western Louisiana, linking missions, settlements, and military posts. |
| 17 | Captain John Smith Chesapeake National Historic Trail | 2006 | Follows the waterways explored by Captain John Smith during his 1608 voyages through the Chesapeake Bay and its tributaries. |
| 18 | Star-Spangled Banner National Historic Trail | 2008 | Commemorates the people, places, and routes associated with the War of 1812 and the events that inspired Francis Scott Key to write the national anthem. |
| 19 | Washington-Rochambeau Revolutionary Route National Historic Trail | 2009 | Follows the 1781 route taken by American and French forces under George Washington and the Comte de Rochambeau during the Yorktown campaign. |
| 20 | Chilkoot National Historic Trail | 2022 | Preserves the Alaska portion of the historic Chilkoot route, a Tlingit trading route that became a major gateway for stampeders heading to the Klondike Gold Rush. |
| 21 | Butterfield Overland National Historic Trail | 2023 | Follows the approximately 3,292-mile route of the Butterfield Overland Mail Company, which carried mail and passengers between St. Louis/Memphis and San Francisco from 1858 to 1861. |